By Rohan Walker
The basic science grouping at the Hunter Medical Research Institute has been very busy over the course of the last year. We have now developed and validated a robust and non-invasive biological measure of chronic stress. Here the CRE’s support for senior postdoctoral researcher Dr Lin Ong has been incredibly important to developing this technology. We are now working with the Hunter New England Area Health service, in collaboration with researchers at the Florey, to implement the first longitudinal study of stress levels in stroke survivors using an objective biometric evaluation. Additionally, the preclinical team has been extensively engaged in investigating degenerative changes that occur within the brain after stroke. We believe that these are very important for understanding the enhanced risk of dementia observed in many patients following stroke. Excitingly, we are also working on a number of potential therapeutic interventions. While in their early phases, these interventions, appear to be robustly neuroprotective and significantly slow the rate of cognitive decline post stroke. Hopefully there will be much more to come in this space soon!
We have recently published a book chapter: Chronic Stress-induced Changes in Microglia in Determining Vulnerability to Mood Disorders and published Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice in J Cereb Blood Flow Metab.