The Basic Science stream research focus is on the development of new interventions for stroke rehabilitation and brain recovery.

The most common problems that interfere with rehabilitative processes, and therefore recovery, are ongoing psychological stress, post-stroke fatigue and late-onset secondary neurodegeneration.

The first phase of the research is the development of reliable clinical assessments for chronic stress through the use of hair stress hormones along with plasma biomarker of fatigue and neurodegeneration.

The second phase will use targeted animal stroke models to assess the effect of FDA/TGA approved compounds to improve mood, impaired motivation, cognitive function and motor recovery using well-established behavioural, histology and biomolecular assessment procedures.

Michael Nilsson leads this work stream.